Pomc hyperpigmentation
WebJul 6, 2011 · POMC knockout (POMC-/-) mice models show a similar phenotype with adrenal insufficiency, marked obesity and altered pigmentation. These POMC-/-mice also have higher fat mass than age-matched normal wildtype (WT) mice and a reduced basal metabolic rate. Their total plasma T4 levels were significantly lower than those of WT mice. WebKim My is an academic researcher from St Mary's Hospital. The author has contributed to research in topic(s): Hamartoma & Neurofibromatosis. The author has an hindex of 1, co-authored 1 publication(s) receiving 9 citation(s).
Pomc hyperpigmentation
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WebExpression of melanocortin 1 receptor before and after narrowband UVB phototherapy treatment in patients with stable vitiligo: A prospective study WebMoreover, increase in phosphorylated ERK1/2 and CREB levels and melanogenesis-specific molecules is induced by mutated SASH1 alleles. Together, our results suggest that a novel SASH1/MAP2K2 crosstalk connects ERK1/2/CREB cascade with p53-POMC-MC1R cascade to cause hyperpigmentation phenotype of DUH.
WebMar 9, 2007 · Here we provide biochemical and genetic evidence demonstrating that UV induction of POMC/MSH in skin is directly controlled by p53. Whereas p53 potently … Hyperpigmentation can be caused by sun damage, inflammation, or other skin injuries, including those related to acne vulgaris. People with darker skin tones are more prone to hyperpigmentation, especially with excess sun exposure. Many forms of hyperpigmentation are caused by an excess production of melanin. Hyperpigmentation can be diffuse or focal, affecting such areas as the face and the back of the …
WebJun 9, 2024 · Proopiomelanocortin (POMC) deficiency is an extremely rare inherited autosomal recessive disorder characterized by severe obesity, adrenal insufficiency, skin hypopigmentation, and red hair. It is caused by pathogenic variants in the POMC gene that codes the proopiomelanocortin polypeptide which is cleaved to several peptides; the most … WebSep 1, 2006 · Proopiomelanocortin (POMC) is a complex propeptide encoding a range of melanocortin peptides that are released by tissue-specific proteolytic processing ().These …
WebDec 15, 2024 · POMC cleavage also releases β-endorphin, which creates a neuroendocrine pathway that promotes UV-seeking behaviours. Mutations along the tanning pathway can affect pigmentation and increase the risk of skin malignancies. MC1R variants have received considerable attention, yet the allele is highly polymorphic with varied phenotypes.
WebOct 30, 2024 · The most common adverse events were injection site reactions, hyperpigmentation, and nausea and vomiting. Taken together, setmelanotide seems most … citic intlWebA. Addison disease is an autoimmune disorder in which the body attacks the adrenal glands, effectively shutting them down. Patients end up with a whole host of problems, including … diaphragmatic injury x rayWebHistologic and electron paramagnetic resonance spectrometry examination demonstrated that hair follicles in back skin of Pomc-/- mice developed with normal structure and … diaphragmatic lobulationPro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during … See more POMC is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core vesicles that are released from the cells by exocytosis in response to appropriate stimulation: See more The large molecule of POMC is the source of several important biologically active substances . POMC can be cleaved enzymatically into the following peptides: • See more A deletion mutation common in Labrador Retriever and Flat-Coated Retriever dogs is associated with increased interest in food and subsequent obesity. See more The POMC gene is located on chromosome 2p23.3. The POMC gene is expressed in both the anterior and intermediate lobes … See more The levels of proopiomelanocortin (pomc) are regulated indirectly in some animals by the photoperiod. It is referred to the hours of light during a day and it changes across the seasons. Its … See more Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. A study concluded … See more POMC is used as a target for a medication used to treat obesity in humans. The combination of bupropion and naltrexone acts via hypothalamic POMC neurons to decrease appetite. See more diaphragmatic injuryWebDescription: Homo sapiens proopiomelanocortin (POMC), transcript variant 1, mRNA. RefSeq Summary (NM_001035256): This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites … diaphragmatic lymphadenopathyWebJul 21, 2016 · Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC … diaphragmatic ligationWebMar 9, 2007 · Normal synthesis of α-MSH and ACTH is an important determinant of constitutive human pigmentation and the cutaneous response to UV (Lunec et al., 1990, … citic investment and data analysis